Much of the research in the Ploegh lab is in the fields of biochemistry and immunology, which started with a specific focus on unraveling the mechanisms by which MHC molecules interact with antigens inside a cell. Later, while at the Whitehead Institute, the Ploegh lab began using a technique called ‘sortagging’ to look at the pathways through which viruses are able to avoid detection by the immune system. Ploegh has been involved in further developing therapeutic roles for sortagging. Additionally, the Ploegh lab now focuses on utilizing ‘nanobodies’, derived from the antibodies of alpaca’s. Much of the research currently done in the lab uses these nanobodies for fundamental research and therapeutic applications.
Hidde Ploegh’s laboratory is interested in the biochemistry of immune recognition, and in mechanisms by which pathogens avoid being seen by the immune system. His earlier work centered on the analysis of the biochemical pathways involved in antigen processing and presentation by the products of the Major Histocompatibility Complex (MHC), which led to studies into glycoprotein biosynthesis and trafficking more generally. The discovery that human cytomegalovirus ex
The Ploegh laboratory is interested in molecular aspects of immune recognition. This pursuit is complemented by the development of new technologies. These include the application of enzymatic methods for site-specific labeling of proteins. We then apply these methods to the modification of nanobodies, the smallest antibody-derived fragments that retain the capacity to bind antigens. The past few years have seen a focus on discovery of alpaca-derived nanobodies that recognize surface antigens on lymphocytes and myeloid cells. When properly modified with fluorophores or radioisotopes, the labeled nanobodies can be used for imaging applications, both for microscopy and to perform whole animal non-invasive imaging experiments by positron emission tomography (PET). The latter approach has been useful in examining the response to checkpoint blocking antibodies We are now developing a suite of nanobodies that can be used in phenotypic screens to perturb intracellular protein-protein interactions, a concept that we have applied to the discovery of nanobodies with antiviral activity.
The enzymatic methods for protein modification are exploited also in the manipulation of immune response
Hidde Ploegh (born in the Netherlands) is an immunologist at Boston Children’s Hospital. He is well-known for his contributions in understanding antigen processing and the evasion of the immune system by viruses.
Ploegh received a Bachelor of Science degree in , and a Master of Science degree in biology and chemistry in , from the University of Groningen. Having worked for six months in Jack Strominger’s lab at that time, he was able to continue his PhD studies under Strominger and received a doctorate from the University of Leiden. Ploegh then proceeded with several positions at a number of institutions such as the University of Cologne, the Netherlands Cancer Institute, Utrecht University (), Harvard Medical School, and the Whitehead Institute. In Ploegh became a member of EMBO. In , Hidde Ploegh became a correspondent of the Royal Netherlands Academy of Arts and Sciences and was elected to the National Academy of Sciences in
Much of the research in the Ploegh lab is in the fields of biochemistry and immunology, which started with a specific focus on the unraveling the mechanisms by which MHC molecules interact with antigens inside a cell. Later, while at the Whitehea
Hidde Ploegh joins Whitehead Institute faculty
CAMBRIDGE, Mass. (March 30, ) — Molecular biologist Hidde Ploegh has just been appointed to the faculty of Whitehead Institute for Biomedical Research.
An acclaimed researcher whose work focuses on the immune system, Hidde comes to Whitehead from the Harvard Medical School where, as Professor of Pathology, he has been heading the school’s immunology program since Prior to that, Ploegh was a Professor of Biology at MIT, working primarily in the Center for Cancer Research.
For many years, Ploegh has been interested in the molecular mechanisms by which the immune system responds to antigens—substances such as toxins, bacteria, or foreign cells from transplants which, when entering the body, trigger the production of antibodies. Recently he’s focused on how certain viral proteins interfere with this process.
Ploegh’s research has contributed in many ways to our understanding of the immune system. For example, he helped elucidate how a certain set of glycoproteins—molecules that help the immune system recognize invaders—are put together and are delivered to the right destination to help an immune response kick in. He discovered a new
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